She has had multiple songs top the Latin charts and has hosted the Latin Grammy Awards eight different times. She starred in the films Caquetá, Delinquent, Fibered de Amor, Escapade Coming, Queasier Seer Hombre, Delicious Sinverguenza, and Zapata: El Sueno De Un Heroe. She has also starred in the telenovelas Chispita, Cuando llega el amor, Los Parientes Pobres, Lazos de Amor, Mi Destino Eres Tu, Alborada, Manana Es Para Siempre, Soy Tu Duena, and Por Ella Soy Eva. Lucero has won more TVyNovelas Awards than any other actress. She has hosted the Teleton Mexico for fourteen years and the Teleton USA raising donations for children with disabilities.