Spencer achieved his greatest success in spaghetti Westerns. He teamed up with fellow Italian Terence Hill and the two made such international hits as Ace High (1968) and They Call Me Trinity (1970). Spencer made 18 movies with Hill. After 1983 Spencer’s movie career slowed down, though he did experience much success in the early ’90s with the TV action-drama series Extralarge. Spencer also wrote screenplays and has registered several patents in his time. In 2005 Spencer entered politics, standing as regional councillor in Lazio for the center-right Forza Italia party.